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DeCS
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Descriptor English:
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Insulin-Like Growth Factor Binding Protein 1
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Descriptor Spanish:
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Proteína 1 de Unión a Factor de Crecimiento Similar a la Insulina
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Descriptor Portuguese:
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Proteína 1 de Ligação a Fator de Crescimento Insulin-Like
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Synonyms English:
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IGF-Binding Protein 1
IGFBP-1
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Tree Number:
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D12.776.157.420.250
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Definition English:
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One of the six homologous proteins that specifically bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions. The function of this protein is not completely defined. However, several studies demonstrate that it inhibits IGF binding to cell surface receptors and thereby inhibits IGF-mediated mitogenic and cell metabolic actions. (Proc Soc Exp Biol Med 1993;204(1):4-29) |
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Indexing Annotation English:
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/biosyn /drug eff /physiol /ultrastruct permitted; DF: note short X refs
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History Note English:
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2005(1992)
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Allowable Qualifiers English:
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Record Number:
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32715
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Unique Identifier:
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D018970
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Occurrence in VHL:
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Similar:
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DeCS SciELO LILACS LIS
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